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Metabolic abnormalities in hypertension

L C Afonso1, G W Edelson, J R Sowers

  • 1Division of Endocrinology, Metabolism and Hypertension, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Current Opinion in Nephrology and Hypertension
|May 1, 1997
PubMed
Summary
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Hypertension is linked to metabolic issues like insulin resistance and obesity. Understanding these connections is key to managing cardiovascular disease risks in hypertensive patients.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Endocrinology

Background:

  • Hypertension frequently coexists with metabolic abnormalities.
  • Insulin resistance, hyperinsulinemia, and obesity are associated with hypertension.
  • Metabolic disturbances contribute to cardiovascular complications.

Purpose of the Study:

  • To review metabolic disturbances associated with hypertension.
  • To explore the pathophysiologic mechanisms involved.
  • To highlight the interplay of these factors in disease complications.

Main Methods:

  • Literature review of clinical and epidemiologic studies.
  • Analysis of prospective study data.
  • Examination of pathophysiologic mechanisms.

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Main Results:

  • Fasting hyperinsulinemia predicts coronary artery disease.
  • Hyperinsulinemia and diabetes reduce sex differences in coronary artery disease prevalence.
  • Hyperandrogenism may promote metabolic dysfunction in women.

Conclusions:

  • Metabolic defects are integral to hypertension.
  • Understanding these links is crucial for managing hypertension and its complications.
  • Further research into pathophysiologic mechanisms is warranted.