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[Development of an anti-HIV gene therapy based on the antiviral properties of beta interferon]
E De Maeyer1, V Vieillard, I Cremer
1UMR 177 du CNRS, Institut Curie, Centre Universitaire, Orsay.
Abstract:
The aim of our work is to explore the use of IFN-beta for gene therapy in the HIV-infection. Transduction of various HIV target cells with a retroviral vector that carries the Hu-IFN-beta coding sequence under constitutive low expression control, confers resistance to HIV without affecting cell replication or function. After transduction, lymphocytes from HIV-infected patients develop resistance to the endogenous virus, provided the cells are derived from individuals with a CD4 cell count higher than 200 per mm3.