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Esophageal candidiasis in HIV-negative patients
J A Ortuño Cortés1, A Tovar Martínez, J Ruiz Riquelme
1Unidad de Gastroenterología, Hospital General de Area, Elda, Alicante.
Revista Espanola De Enfermedades Digestivas
|July 1, 1997
Summary
Candida esophagitis, a common esophageal infection, can occur in HIV-negative individuals. This study characterized the disease in this population, noting varied symptoms and predisposing factors like diabetes and corticotherapy.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Internal Medicine
Background:
- Candida esophagitis is a frequent esophageal infection in both HIV-positive and HIV-negative individuals.
- Understanding its characteristics in HIV-negative patients is crucial for accurate diagnosis and management.
Purpose of the Study:
- To determine the clinical, endoscopic, and etiological characteristics of Candida esophagitis in HIV-negative patients within a general hospital setting.
Main Methods:
- Retrospective analysis of clinical records of HIV-negative patients diagnosed with Candida esophagitis.
- Diagnosis confirmed endoscopically and microscopically via biopsy or cytology.
Main Results:
- Thirty-one HIV-negative patients were identified, with dysphagia and pain as common symptoms.
- Predisposing factors included diabetes mellitus, corticotherapy, malignancies, and broad-spectrum antibiotics; however, 29% had no known risk factors.
- Associated esophagogastroduodenal lesions were common, and mortality was linked to underlying conditions.
Conclusions:
- Candida esophagitis in HIV-negative patients can be infrequent and may present without typical symptoms or known risk factors.
- Aerosolized corticotherapy is identified as a potential risk factor for developing esophageal candidiasis.