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Assessment of liver function: pre- and peritransplant evaluation
A Shaked1, F A Nunes, K M Olthoff
1Department of Surgery, University of Pennsylvania, Philadelphia, USA. shaked@mail.med.upenn.edu
Clinical Chemistry
|August 1, 1997
Summary
Liver transplantation offers high survival for end-stage liver disease. This review details methods for assessing liver function before, during, and after transplant to optimize outcomes.
Area of Science:
- Hepatology
- Transplant Surgery
- Medical Diagnostics
Background:
- Liver transplantation is a life-saving procedure for end-stage liver disease.
- Increased survival rates have expanded transplant indications.
- Organ availability is a major limitation for liver transplantation.
Purpose of the Study:
- To review clinical and laboratory assessments for liver transplantation.
- Focus on pretransplant liver function, donor graft quality, and posttransplant monitoring.
- To guide optimal patient selection and management.
Main Methods:
- Review of existing clinical assessment pathways.
- Analysis of laboratory tests for liver reserve.
- Evaluation of methods for assessing donor liver graft quality.
- Description of posttransplant graft function monitoring techniques.
Main Results:
- Established methods exist for assessing pretransplant liver function.
- Donor liver graft assessment is crucial for transplant success.
- Immediate posttransplant monitoring aids in early complication detection.
- Accurate assessment improves patient selection and graft utilization.
Conclusions:
- Optimizing liver transplantation requires comprehensive pre- and post-transplant assessments.
- Improved assessment strategies can enhance patient survival and graft longevity.
- Further research into novel biomarkers and techniques is warranted.