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Keeping calcium in its place: Ca(2+)-ATPase and phospholamban
1Skirball Institute for Biomolecular Medicine, New York University Medical Center, New York, NY 10012, USA. stokes@saturn.med.nyu.edu
Current Opinion in Structural Biology
|August 1, 1997
Abstract:
Electron microscopy is gradually revealing more and more about the structure of the calcium pump from the sarcoplasmic reticulum, Ca(2+)-ATPase. The most recent result reveals the ATP-binding site, and two different avenues are being pursued towards achieving a higher resolution structure. Although no such structures are currently available for phospholamban, various spectroscopies and site-directed mutagenesis have been combined to produce a compelling structural model for its regulation of Ca(2+)-ATPase.