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Postejaculation serum prostate-specific antigen level

A Zisman1, Y Soffer, Y I Siegel

  • 1Department of Urology, Assaf Harofeh Medical Center, Zerifin, Israel.

European Urology
|January 1, 1997
PubMed
Summary
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Ejaculation significantly elevates serum prostate-specific antigen (PSA) levels, with a median increase of 54%. Therefore, men should abstain from ejaculation for 24 hours before PSA testing for accurate results.

Area of Science:

  • Urology
  • Andrology
  • Biochemistry

Background:

  • Prostate-specific antigen (PSA) is a key biomarker in prostate health.
  • Understanding factors that influence PSA levels is crucial for accurate diagnostic interpretation.

Purpose of the Study:

  • To determine if ejaculation affects serum PSA levels.
  • To assess the relevance of postejaculation serum PSA in male hypofertility evaluations.

Main Methods:

  • Serum PSA was measured in 34 men (18 healthy, 16 with male-factor infertility) before and 1 hour after ejaculation.
  • PSA changes (delta) were analyzed to quantify the effect of ejaculation.

Main Results:

  • A statistically significant increase in serum PSA was observed after ejaculation (p = 0.0037).

Related Experiment Videos

  • Approximately 74% of subjects showed a rise in PSA, with a median relative increase of 54%.
  • No significant differences in PSA change were noted between healthy men and those with infertility.

    • Conclusions:

    • Ejaculation causes a significant elevation in serum PSA.
    • It is recommended that men abstain from ejaculation for 24 hours before PSA testing.
    • Postejaculation PSA levels did not show a significant correlation with male hypofertility.