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Coenzyme Q changes in liver and plasma in the rat after partial hepatectomy
C Castelluccio1, G Formiggini, M Merlo Pich
1Department of Biochemistry G. Moruzzi, University of Bologna, Italy.
Molecular Aspects of Medicine
|January 1, 1997
Abstract:
The levels of coenzyme Q were determined in blood plasma and regenerating liver mitochondria of hepatectomized rats, using as controls either sham-operated or non-operated animals. Mitochondrial CoQ9 content increased in sham-operated rats, whereas it was significantly lower in hepatectomized with respect to non-operated animals. Plasma CoQ9 levels decreased dramatically in hepatectomized animals, but increased strongly in sham-operated in comparison with non-operated rats. The data suggest the possibility of a rate-limiting step in CoQ biosynthesis in hepatectomized animals.