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Active-site studies of enzymes by X-ray diffraction methods
1Laboratorio de Biofísica Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
Biological Research
|January 1, 1996
Abstract:
X-Ray diffraction is the only method currently available for the determination of the detailed three-dimensional structure of macromolecules. In this article, the principles behind the use of X-ray crystallography in the study of protein structure are presented. The results obtained in its application to several enzymes are discussed, as well as the limitations of the method.