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Keratoprosthesis results in animals: an update
Summary
Modified KPro devices show improved retention rates in animal models. However, early dry-eye models experienced significant failures, indicating areas for further development in keratoprosthesis technology.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Veterinary Medicine
Background:
- Continuing development of modified Poly(2-hydroxyethyl methacrylate) (PHEMA) core-and-shirt keratoprostheses (KPros) in animal models.
- Focus on prototype Chirila KPro designs with core-and-skirt configurations.
Purpose of the Study:
- To assess the clinical success rate of two modified Chirila KPro versions: an improved wet-eye model and a dry-eye model.
- To evaluate the performance and retention rates of these novel keratoprosthesis designs.
Main Methods:
- Description of two Chirila KPro variations: improved wet-eye and dry-eye models.
- Clinical assessment of implantation success rates in animal subjects.
- Evaluation of device retention and early failure modes.
Main Results:
- The improved wet-eye model demonstrated a significant enhancement in retention rate.
- The dry-eye model exhibited early failure in two out of three implanted devices.
- Retention rates varied significantly between the two KPro designs.
Conclusions:
- The improved strength of the modified KPro design is significant for retention.
- Early failures in the dry-eye KPro model necessitate further investigation and design refinement.
- Ongoing research aims to optimize keratoprosthesis performance and address specific ocular surface conditions.