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Biperiden and haloperidol plasma levels and extrapyramidal side effects in schizophrenic patients
K Meszaros1, E Lenzinger, K Hornik
1Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria.
Neuropsychobiology
|January 1, 1997
Abstract:
Anticholinergic drugs such as biperiden are used for the treatment of extrapyramidal side effects (EPS) induced by neuroleptics such as haloperidol. The effects of biperiden and haloperidol plasma levels on EPS were studied in 29 chronically ill schizophrenics. The results show relationships between biperiden dose and biperiden plasma levels (BPL), and between BPL and haloperidol plasma levels (HPL). Neither BPL nor HPL seem to influence EPS.