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Anticardiolipin antibodies and retinal vascular complications in Behçet's disease
Y Ozdemir1, F Onder, A Yarangümeli
1Department of Ophthalmology, Ankara Numune Hospital, Turkey.
Insights
Serum anticardiolipin antibodies were investigated in Behçet's disease (BD) patients. No significant link was found between elevated anticardiolipin (aCL) levels and retinal vascular issues in this BD cohort.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Behçet's disease (BD) is characterized by intravascular thrombosis.
- Retinal vascular complications are a known manifestation of BD.
Purpose of the Study:
- To investigate the association between serum anticardiolipin (aCL) antibodies and retinal vascular complications in patients with Behçet's disease.
Main Methods:
- Serum aCL antibody levels were measured using ELISA in 31 BD patients.
- Patients were assessed for retinal vascular complications.
- Statistical analysis included chi-squared and Fisher exact tests.
Main Results:
- Among 12 patients with high aCL antibody levels, 5 had retinal vascular thrombosis and 8 had retinal vasculitis.
- No statistically significant correlation was observed between elevated serum aCL antibody levels and retinal vascular complications (P > .05).
Conclusions:
- This study suggests no significant correlation between serum aCL antibody levels and retinal vascular complications in Behçet's disease.
- Further research may be needed to elucidate the pathogenesis of retinal vascular issues in BD.
Background And Objective:
Intravascular thrombosis is a well-recognized feature of Behçet's disease (BD). In this study, the existence of a connection between serum anticardiolipin (aCL) antibodies and retinal vascular complications in BD is investigated.
Patients And Methods:
Serum aCL antibody levels were quantified in 31 patients with BD, all of whom fulfilled the major criteria of the disease. Patients were evaluated in terms of retinal vascular complications. Serum aCL antibody levels were determined through the ELISA method. Statistical analysis was performed with the chi-squared test and the Fisher exact test.
Results:
Of 12 patients with high aCL antibody levels, retinal vascular thrombosis was detected in 5 and retinal vasculitis was present in 8. However, there was no statistically significant relation between these complications and serum aCL antibody elevation (P > .05).
Conclusion:
Based on this series of 31 patients with BD, there does not seem to be a significant correlation between retinal vascular complications and serum aCL antibody levels.