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Related Experiment Videos

Pharmaceutical processing with supercritical carbon dioxide

B Subramaniam1, R A Rajewski, K Snavely

  • 1Department of Chemical and Petroleum Engineering, and Center for Drug Delivery Research, University of Kansas, Lawrence 66045, USA.

Journal of Pharmaceutical Sciences
|August 1, 1997
PubMed
Summary
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Environmentally benign carbon dioxide is emerging as a green solvent for pharmaceutical processing, enabling clean drug synthesis and particle formation. Further research is needed for continuous production and reproducible product characteristics for industrial scale-up.

Area of Science:

  • Green Chemistry and Pharmaceutical Engineering
  • Sustainable Chemical Processing

Background:

  • Traditional solvents in pharmaceutical processing pose environmental concerns.
  • Growing interest in "environmentally benign" alternatives like carbon dioxide.
  • Carbon dioxide offers potential for "clean" synthesis and particle formation.

Purpose of the Study:

  • To provide an overview of emerging carbon dioxide-based pharmaceutical processing technologies.
  • To highlight the potential for large-scale application in the pharmaceutical industry.
  • To showcase examples of contaminant-free pharmaceutical compounds processed using these methods.

Main Methods:

  • Overview of particle formation using dense carbon dioxide.
  • Review of "clean" drug compound synthesis utilizing carbon dioxide as a reaction medium.

Related Experiment Videos

  • Laboratory-scale processing of pharmaceutical compounds.

    • Main Results:

    • Demonstration of contaminant-free pharmaceutical compound processing on a laboratory scale.
    • Identification of key applications: particle formation and "clean" synthesis.
    • Highlighting the potential for wide-scale adoption in the pharmaceutical sector.

    Conclusions:

    • Carbon dioxide-based technologies show significant promise for sustainable pharmaceutical manufacturing.
    • Challenges remain in achieving continuous production and reproducible particle characteristics.
    • Mathematical modeling is crucial for understanding thermophysical phenomena and enabling scale-up.