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A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes

B Ortmann1, J Copeman, P J Lehner

  • 1Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA.

Science (New York, N.Y.)
|August 29, 1997
PubMed
Summary

Tapasin is a crucial protein that facilitates the interaction between major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP). Its expression restores normal antigen presentation and immune cell recognition in deficient cells.

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