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Related Experiment Videos

Bedside autonomic function testing in patients with vasovagal syncope

van den Berg1, A J Smit

  • 1Department of Cardiology, University Hospital Groningen, The Netherlands.

Pacing and Clinical Electrophysiology : PACE
|August 1, 1997
PubMed
Summary

Vasovagal syncope (VVS) susceptibility may stem from sympathetic hyporesponsiveness, not vagal issues. Many VVS patients show normal vagal reflexes but impaired sympathetic responses, potentially affecting vasoconstriction.

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Area of Science:

  • Autonomic Nervous System Physiology
  • Cardiovascular Reflexes
  • Neurocardiology

Background:

  • Individual susceptibility to vasovagal syncope (VVS) is not fully understood.
  • The role of the autonomic nervous system in VVS pathogenesis requires further investigation.

Purpose of the Study:

  • To investigate vagal and sympathetic reflex responsiveness in patients with vasovagal syncope.
  • To identify potential autonomic nervous system dysfunctions contributing to VVS.

Main Methods:

  • Studied 12 patients diagnosed with vasovagal syncope.
  • Assessed vagal responsiveness using Valsalva maneuver and deep breathing.
  • Evaluated sympathetic responsiveness via mental arithmetic stress, cold-pressor test, and isometric handgrip.
  • Assessed combined autonomic responsiveness during standing up.

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Main Results:

  • Vagal reflex tests were predominantly normal in VVS patients.
  • Subnormal sympathetic responses were observed in multiple patients during mental stress, cold-pressor test, and isometric handgrip.
  • Autonomic response to standing up was normal in all participants.

Conclusions:

  • Many vasovagal syncope patients exhibit normal vagal function but sympathetic hyporesponsiveness.
  • Sympathetic hyporesponsiveness may contribute to inadequate vasoconstriction, a key factor in VVS.
  • This suggests a potential therapeutic target for managing vasovagal syncope.