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MDR1-Pgp 170 expression in human bronchus

E Lechapt-Zalcman1, I Hurbain, R Lacave

  • 1Histology and Tumour-Biology Laboratory, Hôpital Tenon, Paris, France.

The European Respiratory Journal
|August 1, 1997
PubMed
Summary
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MDR1 P-glycoprotein (Pgp 170) is expressed in human airway epithelial cells and bronchial glands, suggesting a key role in airway defense mechanisms and mucus regulation. This finding highlights Pgp 170

Area of Science:

  • Cell Biology
  • Pulmonary Medicine
  • Biochemistry

Background:

  • MDR1 P-glycoprotein (Pgp 170) is an ATP-binding cassette transporter involved in effluxing hydrophobic agents and xenobiotics.
  • Pgp 170 also regulates cell-volume activated chloride channels, suggesting potential roles in airway physiology.
  • Its precise localization in human airways was previously uncharacterized.

Purpose of the Study:

  • To determine the exact localization of Pgp 170 within human adult airways.
  • To investigate the potential role of Pgp 170 in airway defense and mucus layer composition.

Main Methods:

  • Bronchial specimens were collected from 33 adult patients (smokers, ex-smokers, and non-smokers).
  • MDR1 messenger ribonucleic acid (mRNA) presence was confirmed using reverse transcriptase-chain reaction (RT-PCR).

Related Experiment Videos

  • Immunodetection of Pgp 170 was performed on tissue sections using monoclonal antibodies.

    • Main Results:

    • Pgp 170 mRNA was detected in bronchial epithelial cells from all patient groups.
    • Intense Pgp 170 labeling was observed on the apical surface of ciliated epithelial cells and serous cells of bronchial glands.
    • Pgp 170 was also found on the luminal surface of bronchial capillary endothelial cells, but not in mucus-secreting cells.

    Conclusions:

    • Pgp 170 is consistently expressed in human airway structures, particularly on the apical surface of epithelial cells.
    • This expression suggests significant functions for Pgp 170 in airway defense and regulation of the airway environment.
    • Further research into Pgp 170's role in pulmonary health and disease is warranted.