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Annexin V-coated intraocular lenses
P Chollet1, F Malecaze, P Le Toan
1Department of Ophthalmology, Purpan Hospital, Toulouse, France.
Purpose:
To assess whether annexin V-coated poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) prevent postoperative inflammation in rabbit eyes.
Setting:
Department of Ophthalmology, Hôpital Purpan, Toulouse, France.
Methods:
Thirteen IOLs coated with annexin V were implanted in 13 rabbit eyes; the contralateral eyes received uncoated IOLs. Postoperative fibrin was quantitated by daily slitlamp examination until the anterior chamber was completely clear. Results were analyzed using a Wilcoxon test. Ocular toxicity was evaluated by light and electron microscopy.
Results:
Eyes with the annexin V-coated IOLs had less severe inflammation on the first postoperative day, and the inflammation resolved more quickly than in eyes with uncoated IOLs (P < .05). No annexin V was released postoperatively, nor were there signs of ocular toxicity.
Conclusion:
Annexin V-coated lenses effectively reduced postoperative inflammation in rabbit eyes.