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Related Experiment Videos

Maternal immunization to Gov system alloantigens on human platelets

J O Bordin1, J G Kelton, M N Warner

  • 1Department of Hematology and Transfusion Medicine, Universidade Federal de São Paulo, Escola Paulista de Medicina, Brazil.

Transfusion
|August 1, 1997
PubMed
Summary

Maternal immunization to Gov system platelet antigens can occur during pregnancy, leading to neonatal alloimmune thrombocytopenia. This study identifies three cases of maternal alloimmunization to Gov(a) or Gov(b) antigens.

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Area of Science:

  • Immunology
  • Hematology
  • Reproductive Medicine

Background:

  • Alloimmunization to platelet antigens can arise during pregnancy or via blood transfusions.
  • Platelet alloantibodies are implicated in neonatal alloimmune thrombocytopenia (NAIT) and posttransfusion purpura.
  • The Gov platelet antigen system, expressed on CD109, is a novel system associated with alloimmunization.

Observation:

  • Three unrelated patients presented with alloimmunization to Gov(a) or Gov(b) antigens.
  • Two patients were investigated due to NAIT in their offspring, with maternal serum revealing Gov(b) and Gov(a) specific antibodies.
  • A third patient with idiopathic thrombocytopenia purpura had antibodies to Gov(b) and HPA-5b, likely from pregnancy-related immunization.

Findings:

  • Maternal serum analysis confirmed the presence of alloantibodies against Gov(b) and Gov(a) in the studied patients.

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  • Platelet typing confirmed the patients' susceptibility to alloimmunization against the identified antigens.
  • The Gov system antigens were identified as a cause of maternal alloimmunization.

    • Implications:

    • Maternal immunization to Gov system antigens can occur through placental transfer.
    • Gov system alloantibodies are associated with neonatal alloimmune thrombocytopenia.
    • Understanding Gov system alloimmunization is crucial for managing NAIT and ensuring transfusion safety.