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Updated: Oct 2, 2026

Engineering Cell-permeable Protein
Published on: December 28, 2009
Targeted delivery of peptides, proteins, and genes by receptor-mediated endocytosis
1Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Abstract:
Receptor-mediated endocytosis (RME) is one type of delivery system by which therapeutic agents can be specifically transported to their target. Although many successful studies have been performed at a preclinical level, its clinical application is restricted by a number of factors, including the low targeting efficiency that stems from the characteristics of RME. One important approach to overcome this is to improve the drug delivery system by a series of chemical modifications and evaluate the drug targeting efficiency from a kinetic point of view.
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