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The hypoglycemic effect of chloroquine
The Journal of the Association of Physicians of India
|January 1, 1995
Summary
Intravenous chloroquine significantly lowered blood glucose levels in healthy individuals. Patients receiving IV chloroquine require careful monitoring for potential hypoglycemia, especially if critically ill.
Area of Science:
- Pharmacology
- Clinical Medicine
- Biochemistry
Background:
- Chloroquine is an antimalarial and anti-inflammatory drug.
- Its metabolic effects, particularly on glucose regulation, are not fully understood.
Purpose of the Study:
- To investigate the impact of intravenous chloroquine administration on serum glucose levels in healthy individuals.
Main Methods:
- Ten healthy volunteers received 800 mg of chloroquine via a three-hour intravenous infusion.
- Serum glucose levels were monitored before and after administration.
Main Results:
- A significant decrease of 25.86% in initial blood glucose levels was observed in the chloroquine group (p = 0.001).
- The control group experienced a smaller decrease of 10.47%.
Conclusions:
- Intravenous chloroquine administration can lead to a significant reduction in blood glucose levels.
- Critically ill patients and those prone to hypoglycemia require careful monitoring during IV chloroquine therapy to prevent adverse events.