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Technetium-99m (V)-dimercaptosuccinic acid: normal accumulation in the breasts
Y Nakamoto1, H Sakahara, H Kobayashi
1Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine, Japan.
European Journal of Nuclear Medicine
|September 8, 1997
Summary
Technetium-99m (V)-dimercaptosuccinic acid (DMSA) imaging shows normal breast uptake in women. This finding is important for understanding the biodistribution of this tumor-imaging agent.
Area of Science:
- Nuclear Medicine
- Radiopharmacology
- Medical Imaging
Background:
- Technetium-99m (V)-dimercaptosuccinic acid (DMSA) is an established tumor-imaging agent.
- Its physiological uptake is known in kidneys, nasal mucosa, and blood pool.
- Breast uptake has been anecdotally observed but not systematically evaluated.
Purpose of the Study:
- To retrospectively evaluate the accumulation of 99mTc (V)-DMSA in normal female breasts.
- To determine the prevalence and characteristics of breast uptake in a patient cohort.
Main Methods:
- Retrospective analysis of 83 patients undergoing 99mTc (V)-DMSA imaging.
- Assessment of breast uptake in male and female patients across different age groups.
- Correlation of breast uptake with patient demographics.
Main Results:
- No breast uptake was observed in male patients.
- 24 out of 51 female patients (47%) demonstrated bilateral symmetrical breast uptake.
- Positive uptake was highest in women aged 15-50 years (70%) and decreased in older age groups.
Conclusions:
- Female breasts exhibit normal physiological uptake of 99mTc (V)-DMSA.
- This finding should be incorporated into the standard biodistribution pattern for this agent.
- Understanding normal breast uptake is crucial for accurate interpretation of tumor imaging.