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Glucocorticosteroids as immunosuppressive agents

L A Cohn1

  • 1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.

Seminars in Veterinary Medicine and Surgery (Small Animal)
|August 1, 1997
PubMed
Summary

Glucocorticosteroids modulate immune cell functions, aiding in treating immune-mediated diseases like autoimmunity and transplant rejection. Understanding their mechanisms improves clinical management of these conditions.

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Area of Science:

  • Immunology
  • Pharmacology
  • Endocrinology

Background:

  • Glucocorticosteroids significantly impact immune system components.
  • Their clinical utility is established in managing immune-mediated disorders.

Purpose of the Study:

  • To elucidate the mechanisms of glucocorticosteroid action on immune cells.
  • To enhance clinical decision-making in immune-mediated disease management.

Main Methods:

  • Review of existing literature on glucocorticosteroid effects.
  • Analysis of cellular and molecular immune responses.

Main Results:

  • Glucocorticosteroids alter leukocyte kinetics and function.
  • They suppress cell-mediated and, to a lesser degree, humoral immunity.

Conclusions:

  • Corticosteroids are vital for treating autoimmunity, transplant rejection, and hypersensitivity.
  • Further understanding of mechanisms will refine clinical applications.

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