Nutritional modification of inflammatory diseases

Regulation of the immune system is extremely complex. We are only starting to understand how the immune system coordinates the body's response to a disease or invading pathogen. Immunomodulation, as the term implies, can be used to designate either a suppression or an augmentation of an immune response. Suppressing the function of the immune system may be important in cases of inflammation and augmenting the immune response when increased resistance to disease is required. Nutrition does and can play an important role in modulation of the animal's immune system. The majority of scientific literature published on the interaction of nutrition and the immune system correlates the effects of nutrient deficiency and modulation of an immune response. These studies have evaluated deficiencies of protein; energy; the fat soluble vitamins A, D, and E; the B-complex vitamins; vitamin C; and the minerals selenium, iron, zinc, and copper and their relationship to immune dysfunction. Most recently, researchers have concentrated efforts on evaluating the impact specific fatty acids have on modulation of the immune system. Undoubtedly, the nutritional status of the animal plays an important role in resistance mechanisms against disease causing organisms and may influence the outcome of disease in infected animals. The focus of this chapter is to concentrate on the role specific polyunsaturated fatty acids have on the immune response of animals and to consider the potential for nutritional modification of diseases related to inflammation.