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[Hematologic deficiencies in patients with recurrent oral aphthae]
M A Barnadas1, A Remacha, J Condomines
1Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona.
Medicina Clinica
|June 14, 1997
Summary
Recurrent oral ulcerations (ROU) are linked to higher rates of iron, folic acid, and vitamin B12 deficiencies. These nutrient deficiencies are more common in ROU patients than in other oral conditions.
Area of Science:
- Nutritional Science
- Oral Medicine
- Hematology
Background:
- The link between nutrient deficiencies and recurrent oral ulcerations (ROU) is not well-established.
- Investigating the prevalence of iron, folic acid, and vitamin B12 deficiencies in ROU patients is crucial.
Purpose of the Study:
- To determine the prevalence of iron, folic acid, and vitamin B12 deficiencies in patients experiencing recurrent oral ulcerations.
- To compare these deficiency rates with a control group of patients suffering from other oral diseases.
Main Methods:
- Serum levels of iron, folic acid, and vitamin B12 were analyzed in 80 patients with ROU.
- A control group of 29 patients with various oral diseases was included for comparison.
Main Results:
- Nutrient deficiencies were found in 26.2% (21/80) of ROU patients, compared to 13.7% (4/29) in the control group.
- Isolated deficiencies included iron (4), folic acid (10), and vitamin B12 (4) in ROU patients. Combined deficiencies were noted in 3 ROU patients, two with pernicious anemia.
- Control group deficiencies included ferropenic anemia (1) and pernicious anemia (2).
Conclusions:
- Patients with recurrent oral ulcerations exhibit a higher frequency of iron, folic acid, and vitamin B12 deficiencies.
- No significant differences were observed in the frequency of individual nutrient deficiencies when analyzed separately.