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Multiple malignant meningiomas in a young cat
R G Lobetti1, J W Nesbit, D B Miller
1Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
Journal of the South African Veterinary Association
|June 1, 1997
Summary
Chemotherapy for feline thymic lymphoma may lead to secondary brain tumors. A cat treated for lymphoma developed neurological signs, later diagnosed with multiple meningiomas post-mortem.
Area of Science:
- Veterinary Neurology
- Oncology
- Toxicology
Background:
- A 2-year-old cat received combination chemotherapy (cyclophosphamide, vincristine, prednisolone) for thymic lymphoma, achieving remission.
- The cat later developed progressive neurological deficits, including tremors and ataxia, despite successful lymphoma treatment.
Observation:
- Neurological signs worsened over time, leading to paralysis and death.
- Autopsy revealed multiple meningiomas, a rare finding in this context.
Findings:
- The development of multiple meningiomas is suspected to be a secondary malignancy.
- Chemotherapy for lymphoma may have induced the brain tumors.
Implications:
- This case highlights a potential long-term adverse effect of chemotherapy in felines.
- Further research is needed to understand the link between lymphoma chemotherapy and secondary meningioma development.