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[Role of coagulation disorders in mesenteric ischemia]
1Service d'Onco-Hématologie, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre.
Journal De Chirurgie
|January 1, 1996
Summary
Inherited thrombophilia is a significant cause of mesenteric vein thrombosis, ranking third in occurrence after lung and leg sites. Genetic defects and acquired conditions contribute to this condition, with new insights aiding diagnosis and treatment.
Area of Science:
- Vascular Medicine
- Hematology
- Genetics
Context:
- Mesenteric ischemia can result in bowel infarction or chronic low-grade ischemia.
- Inherited thrombophilia accounts for 30-40% of mesenteric vein thrombosis cases.
- Mesenteric thrombosis is a notable thromboembolism site, comparable to cerebral thrombosis.
Purpose:
- To discuss genetic defects associated with thrombophilia, including protein C, protein S, antithrombin III deficiencies, and dysfibrinogenemia.
- To highlight the significance of resistance to activated protein C.
- To review acquired conditions like myeloproliferative disease and paroxysmal nocturnal hemoglobinemia that induce thrombosis.
Summary:
- Inherited thrombophilia is a key factor in mesenteric vein thrombosis.
- Genetic defects (e.g., protein C deficiency) and acquired conditions contribute to thrombophilia.
- Mesenteric thrombosis is a significant thromboembolic event.
Impact:
- Recent research offers new insights for improved diagnostic and therapeutic strategies.
- Understanding thrombophilia's role in mesenteric ischemia can enhance patient outcomes.
- This review integrates current knowledge for clinical application.