[Distribution of radioactive tetanus toxin at the subcellular level]

Experiments were carried out on rabbits for detecting the distribution of radioactive tetanotoxin between subcellular fractions of tissues of the central nervous system. It has been found out that a parenteral administration of tetanotoxin-35S results in a quick rise of the tissue radioactivity. The radioactivity of the free ribosome fraction remained most constant and high, which might be an indication of a high acceptory capacity of these organelles to tetanotoxin. For some periods of an acute tetanus intoxication, a rather high tropism of tetanotoxin of synaptosome, microsome and myelinic fragments was found.