Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cutaneous leiomyosarcoma

S Kaddu1, A Beham, L Cerroni

  • 1Department of Dermatology, University of Graz, Austria.

The American Journal of Surgical Pathology
|September 23, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First presentation of a frameshift mutation in the SETD2 gene of a juvenile psammomatoid ossifying fibroma (JPOF) associated with an aneurysmal bone cyst.

Diagnostic pathology·2021
Same author

Long-term clinical outcomes of imiquimod 5% cream vs. diclofenac 3% gel for actinic keratosis on the face or scalp: a pooled analysis of two randomized controlled trials.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Pioneers in dermatology and venereology: an interview with Prof. Helmut Kerl.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same author

Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding.

Langenbeck's archives of surgery·2017
Same author

[Implementation of Robot-Assisted Surgery].

Zentralblatt fur Chirurgie·2016
Same author

AK progressing to NMSC: at what stage?

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same journal

Clinicopathologic and Molecular Analysis of Traditional Serrated Adenoma and Its Possible Precursor Lesions With Special Reference to RSPO Fusion Status: A Large Case Series From Single Institution.

The American journal of surgical pathology·2026
Same journal

NF2/Merlin Immunohistochemistry Helps Distinguish Collecting Duct Carcinoma From Upper Tract Urothelial Carcinoma.

The American journal of surgical pathology·2026
Same journal

Neuroendocrine Carcinoma of the Gallbladder: Clinicopathologic and Immunohistochemical Analysis of 31 Cases.

The American journal of surgical pathology·2026
Same journal

Papillary Renal Neoplasm With Reverse Polarity Is a Distinct Distal Nephron-Derived Tumor With Unique Methylation Profile.

The American journal of surgical pathology·2026
Same journal

Biallelic ARID1A Alterations: A Promising Novel Biomarker for Risk Stratification and Management in Pediatric Malignant Hepatocellular Tumors.

The American journal of surgical pathology·2026
Same journal

Absent Cyclin D1 Expression in Myeloid Sarcomas Distinguishes From Malignant Histiocytic Neoplasms: When Morphologic Ambiguity is Deceptive.

The American journal of surgical pathology·2026
See all related articles

Cutaneous leiomyosarcoma, a rare skin cancer, presents with varied growth patterns and immunophenotypes. While local recurrences occur, distant metastasis is rare, highlighting diagnostic challenges and the need for comprehensive immunohistochemistry.

Area of Science:

  • Dermatopathology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Cutaneous leiomyosarcoma is a rare malignancy arising from smooth muscle tissue.
  • Understanding its histopathologic and immunohistologic features is crucial for accurate diagnosis and patient management.

Purpose of the Study:

  • To analyze the clinical, histopathologic, immunohistologic, and prognostic features of cutaneous leiomyosarcoma.
  • To identify diagnostic challenges and prognostic indicators for this rare skin cancer.

Main Methods:

  • Retrospective review of 19 patients with cutaneous leiomyosarcoma.
  • Histopathologic and immunohistologic analysis using a panel of antibodies (vimentin, smooth muscle actin, HHF-35, desmin, cytokeratins, S-100 protein).
  • Clinical follow-up to assess recurrence and metastasis.

Related Experiment Videos

Main Results:

  • Two main growth patterns observed: nodular (high cellularity, atypia, necrosis) and diffuse (low cellularity, well-differentiated cells, minimal necrosis).
  • Immunohistochemistry showed consistent expression of vimentin and smooth muscle actin; variable expression of HHF-35 and desmin; cytokeratin expression in some cases.
  • Local recurrence observed in 5/19 patients; no distant metastases reported.

Conclusions:

  • The diffuse growth pattern of cutaneous leiomyosarcoma can be diagnostically challenging due to subtle malignant criteria.
  • A broad panel of immunohistochemical markers is essential for accurate diagnosis.
  • Cutaneous leiomyosarcoma has a low potential for distant metastasis but a risk of local recurrence.