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Idiopathic myelofibrosis with neutrophil myeloperoxidase deficiency: a case report
A Caenazzo1, E Piva, D Sartori
1Chair of Internal Medicine, University of Padua, Italy.
Haematologica
|July 1, 1997
Abstract:
We describe a case of idiopathic myelofibrosis with total neutrophil myeloperoxidase deficiency. The combination of this enzymatic defect with myelofibrotic changes in the nuclear shape of neutrophils confers a peculiar appearance on leukograms produced by a Technicon H*1. The clinical course of the disease was shortened by recurrent infections that may be ascribed, at least in part, to reduced leukocyte microbicidal ability.