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Genetic heterogeneity of migraine with and without aura in Danes cannot be explained by mutation in mtDNA nucleotide
M B Russell1, M Diamant, S Nørby
1Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
Introduction:
Migraine is a genetic heterogeneous disorder. The 11084 A to G base substitution is in the gene for the ND4 subunit of the respiratory complex I, and leads to a Thr to Ala amino acid replacement. This mutation had been found in 25% of Japanese migraineurs, while tension-type headache sufferers and non-migraineurs did not have it.
Material And Methods:
We investigated the importance of this mutation in Danish migraineurs without aura, migraineurs with aura and non-migraineurs from the general population.
Results:
We did not detect this mutation in Danes.
Conclusion:
Our result excludes a significant role of this mutation in the etiology of migraine in Denmark, and its absence in non-migraineurs supports that this mutation is rare in non-Japanese populations.