Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging rat vestibular ganglion: II. Quantitative electron microscopic evaluation

M J Lyon1, J M King

  • 1Department of Otolaryngology and Communication Sciences, State University of New York Health Science Center, Syracuse 13210, USA.

The Annals of Otology, Rhinology, and Laryngology
|September 26, 1997
PubMed
Summary

Aging Wistar rats show significant intracellular changes in vestibular ganglion cells, including reduced mitochondria and protein synthesis capacity, despite no cell loss. These findings suggest impaired metabolic and functional capabilities in aging rats.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergency Department Visit Rates by Selected Characteristics: United States, 2021.

NCHS data brief·2023
Same author

Emergency Department Visit Rates by Selected Characteristics: United States, 2020.

NCHS data brief·2022
Same author

The X-Ray in Dentistry.

The Dental register·2021
Same author

An Easy Method of Making a Gold Crown for Anterior Teeth.

The American journal of dental science·2019
Same author

Plasmalemma fine structure in isolated tobacco mesophyll protoplasts.

Planta·2014
Same author

The use of antibiotics in the culture of non-sterile plant protoplasts.

Planta·2014

Area of Science:

  • Neuroscience
  • Cell Biology
  • Gerontology

Background:

  • Age-related vestibular ganglion cell loss occurs in humans, but not Wistar rats.
  • Previous studies noted intracellular changes in aging rat vestibular ganglion cells.

Purpose of the Study:

  • To quantify intracellular changes in aging Wistar rat vestibular ganglion cells.
  • To assess age-related alterations in mitochondria, RER, Golgi apparatus, and aging pigment.

Main Methods:

  • Electron microscopy and stereological techniques were used.
  • Volume densities of cellular components and cell diameter were measured.
  • Young (3-5 months) and old (24-31 months) female Wistar rats were studied.

Main Results:

Related Experiment Videos

  • Significant decreases observed in mitochondria (11.4%), Golgi apparatus (8.1%), and RER (8.9%) volume densities.
  • A substantial increase (327%) in aging pigment was noted.
  • No significant change in mean vestibular ganglion cell profile diameter was found.

Conclusions:

  • Aging Wistar rats exhibit decreased mitochondrial and RER volume densities, suggesting reduced oxidative metabolism and protein synthesis.
  • Increased aging pigment indicates cellular stress or damage.
  • These cellular changes suggest impaired metabolic and functional capabilities in aging vestibular ganglion cells, potentially impacting sensory input.