Related Experiment Video
Updated: Aug 1, 2026

10:52
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
Published on: September 21, 2015
Traumatic brain injury/chronic pain syndrome: a case comparison study
M T Andary1, N Crewe, S K Ganzel
1College of Osteopathic Medicine, Michigan State University, East Lansing 48823, USA.
The Clinical Journal of Pain
|September 26, 1997
Summary
Chronic pain patients with undiagnosed traumatic brain injury (TBI) often require longer treatment but achieve similar employment outcomes. Early identification of TBI in chronic pain patients is crucial for effective rehabilitation and successful return to work.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Pain Management
Background:
- Many chronic pain patients may have co-occurring, undiagnosed traumatic brain injuries (TBI).
- Identifying and treating TBI alongside chronic pain is essential for comprehensive patient care.
- Understanding the characteristics and outcomes of patients with dual diagnoses is critical for optimizing treatment strategies.
Purpose of the Study:
- To compare the pretreatment characteristics, treatment progress, and outcomes of chronic pain patients with and without concomitant traumatic brain injury (TBI).
- To identify key indicators for potential TBI in chronic pain populations.
- To evaluate the impact of TBI on treatment duration and vocational success in chronic pain patients.
Main Methods:
- A retrospective cohort study compared 12 chronic pain patients with untreated TBI to 12 matched chronic pain patients without TBI.
- Patients were treated in an interdisciplinary outpatient rehabilitation medicine clinic.
- Key outcome measures included treatment duration and vocational outcomes.
Main Results:
- A significant proportion of chronic pain patients (21 of 65) showed signs of previously undiagnosed mild TBI.
- Patients with TBI were more likely to have automobile-related injuries and less likely to have work-related injuries.
- Both groups achieved a similar increase in employment rates (25% to 75%), but the TBI group required significantly longer treatment (459 days vs. 295 days).
Conclusions:
- Chronic pain patients with cognitive issues, confusion, or specific injury patterns (e.g., automobile accidents, head/neck/arm pain) should be screened for TBI.
- Successful employment outcomes are achievable for most patients, including those with TBI.
- The TBI cohort necessitates a longer treatment duration for comparable vocational success.

