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Two district alpha(1)-adrenoceptor subtypes in the human prostate: assessment by radioligand binding assay using
K Maruyama1, J Fukutomi, T Chiba
1Department of Pharmacology, Niigata College of Pharmacy, Japan.
General Pharmacology
|December 1, 1996
Abstract:
1. We showed that there were two distinct alpha(1)-adrenoceptor subtypes (alpha(1H) and alpha(IL)) in the human prostate which show different affinities for 3H-prazosin. 2. WB4101, tamsulosin, 5-methylurapizil, phentolamin, and terazosin, but not nifedipine, had significantly higher pKi values for the alpha(1H)-subtype than for the alpha(IL)-subtypes. 3. There was good correlation (r = 0.92, P < 0.05) between the pKi values obtained for the alpha(1H)-receptors in membrane fractions and the cloned human alpha(1c)-adrenoceptor subtype.