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Deep venous thrombosis: prediction by D-dimer?

H Kozman1, M C Flemmer, M Rahnama

  • 1Department of Internal Medicine, Eastern Virginia Medical School, Norfolk 23507, USA.

Southern Medical Journal
|September 26, 1997
PubMed
Summary
This summary is machine-generated.

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A qualitative D-dimer assay effectively rules out deep venous thrombosis (DVT) in hospitalized patients when levels are below 2,000 ng/mL. This noninvasive test aids in DVT diagnosis, reducing unnecessary procedures.

Area of Science:

  • Medical Diagnostics
  • Hematology
  • Vascular Medicine

Background:

  • Deep venous thrombosis (DVT) diagnosis often involves costly imaging.
  • D-dimer assays offer a potentially inexpensive, noninvasive diagnostic tool.
  • The clinical utility of qualitative D-dimer for DVT exclusion remains under investigation.

Purpose of the Study:

  • To evaluate the correlation between a qualitative D-dimer assay and the diagnosis of DVT.
  • To determine the efficacy of D-dimer as an exclusionary test for DVT in hospitalized patients.

Main Methods:

  • A prospective study involving 65 hospitalized patients referred for DVT diagnosis.
  • Patients underwent venous duplex and duplex Doppler ultrasonography.
  • Exclusion criteria included conditions associated with elevated D-dimer (inflammation, infection, malignancy).

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Main Results:

  • DVT was diagnosed in 16 out of 65 patients.
  • Mean D-dimer levels were 5,141 ng/mL in patients with DVT and 3,024 ng/mL in those without DVT.
  • A D-dimer level below 2,000 ng/mL was associated with the absence of DVT (0% prevalence).

Conclusions:

  • The qualitative D-dimer assay is a valuable exclusionary test for DVT when levels are below 2,000 ng/mL.
  • This assay can help streamline DVT diagnosis and potentially reduce healthcare costs.
  • Further discussion on D-dimer assay limitations and cost-effectiveness is warranted.