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Primary plasmacytoma of lymph nodes
1Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Human Pathology
|October 6, 1997
Summary
Primary nodal plasmacytoma, a rare condition, shows a favorable prognosis with rare recurrence and no progression to multiple myeloma after treatment. This study confirms its indolent course and effective outcomes with surgical excision or chemotherapy.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Primary plasmacytoma of the lymph nodes is an exceptionally rare malignancy.
- Existing data suggest a better prognosis compared to other extramedullary plasmacytomas.
Purpose of the Study:
- To elucidate the clinicopathological characteristics of primary nodal plasmacytoma.
- To investigate the potential pathogenetic factors involved in this rare entity.
Main Methods:
- Retrospective review of seven cases of primary lymph node plasmacytoma.
- Analysis of clinical data, histopathology, immunohistochemistry, and molecular studies (EBV, KSHV).
Main Results:
- Seven patients (39-76 years) presented with enlarged lymph nodes and an indolent clinical course.
- All patients treated with excision (± chemotherapy) showed no recurrence or progression to multiple myeloma.
- Immunohistochemistry revealed immunoglobulin light chain restriction and monoclonal heavy chain expression; p53, bcl-2, EBV, and KSHV were not implicated.
Conclusions:
- Primary nodal plasmacytoma exhibits a favorable prognosis with rare recurrence and no progression to multiple myeloma.
- Pathogenesis may not involve p53, bcl-2, EBV, or KSHV, suggesting distinct molecular pathways.