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Related Experiment Videos

Transport-in-vitro fertilization/intracellular sperm injection: a prospective randomized study

T Coetsier1, A Verhoeff, P De Sutter

  • 1Department of Obstetrics and Gynaecology, University Hospital, Gent, Belgium.

Human Reproduction (Oxford, England)
|August 1, 1997
PubMed
Summary
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Long distance oocyte transport before intracytoplasmic sperm injection (ICSI) does not impact fertilization or implantation rates. However, embryo quality may be negatively affected by this transport method.

Area of Science:

  • Reproductive Medicine
  • Clinical Embryology
  • Infertility Treatment

Background:

  • Intracytoplasmic sperm injection (ICSI) is a common assisted reproductive technology for treating male infertility.
  • The logistics of ICSI cycles can involve transporting gametes or embryos between facilities.
  • The impact of long-distance oocyte transport on subsequent ICSI outcomes is not well-established.

Purpose of the Study:

  • To evaluate the effect of long-distance oocyte transport on fertilization rates, embryo quality, and implantation rates in ICSI cycles.
  • To compare outcomes between immediate ICSI procedures and those involving oocyte transport.

Main Methods:

  • A prospective randomized clinical trial involving 100 infertile couples undergoing ICSI.
  • Group 1: Oocyte retrieval, ICSI, and embryo transfer in the same location (Gent, Belgium).

Related Experiment Videos

  • Group 2: Oocyte retrieval in Rotterdam (Netherlands) with transport to Gent for ICSI and embryo transfer.

    • Main Results:

    • No significant differences in fertilization rates (P=0.08) or embryo implantation rates (P=0.89) between groups.
    • Group 1 (no transport) had significantly higher numbers of retrieved oocytes (P=0.05) and superior embryo quality, including total score (P=0.01), number of good quality embryos (P=0.02), and embryos for cryopreservation (P=0.03).
    • Mean score of transferred embryos was also higher in Group 1 (P=0.05).

    Conclusions:

    • Long-distance oocyte transport prior to ICSI does not adversely affect oocyte fertilization or embryo implantation rates.
    • A potential negative impact on embryo quality, including total score, good quality embryos, and cryopreservation potential, cannot be excluded with oocyte transport.
    • These findings suggest that while fertilization and implantation are preserved, embryo developmental potential may be compromised by oocyte transport.