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Updated: Aug 11, 2026
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Isolation and Cannulation of Cerebral Parenchymal Arterioles
Published on: May 23, 2016
Cerebral arteriovenous malformation in three successive generations
P D Larsen1, L C Hellbusch, D M Lefkowitz
1Department of Neurology, Creighton University Medical Center, Omaha, Nebraska 68131, USA.
Pediatric Neurology
|July 1, 1997
Summary
A family exhibited cerebral arteriovenous malformations across three generations, indicating an autosomal dominant inheritance pattern. The study discusses screening relatives for this condition.
Area of Science:
- Neurology
- Genetics
- Vascular Medicine
Background:
- Cerebral arteriovenous malformations (cAVMs) are complex vascular anomalies.
- Familial occurrence of cAVMs suggests a genetic component.
Purpose of the Study:
- To investigate the inheritance pattern of cerebral arteriovenous malformations within a kindred.
- To evaluate the implications of familial cAVMs for genetic counseling and screening.
Main Methods:
- Pedigree analysis was conducted for a family with multiple affected individuals.
- Clinical data and family history were reviewed.
Main Results:
- A distinct pattern of affected individuals across three generations was observed.
- Autosomal dominant inheritance is strongly suggested by the family's presentation.
Conclusions:
- Cerebral arteriovenous malformations can exhibit autosomal dominant inheritance.
- Screening of asymptomatic individuals with a positive family history is warranted.
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