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Human papillomavirus and bladder cancer
A Lopez-Beltran1, A L Escudero
1Department of Pathology, Cordoba University Medical School, Spain.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1997
Summary
Human papillomavirus (HPV) DNA is found in bladder cancers, particularly in high-grade tumors. HPV infection may impact patient survival and recurrence rates, suggesting prognostic value in bladder cancer management.
Area of Science:
- Oncology
- Virology
- Urology
Background:
- Human papillomavirus (HPV) deoxyribonucleic acid (DNA) has been detected in urothelial carcinomas, initially in immunocompromised patients.
- Studies in the general population report a wide incidence of high-risk HPV DNA (2.5%–81%), with HPV 16 being most common.
- HPV DNA presence in bladder cancer, though variable, is noted in both papillary and invasive types.
Purpose of the Study:
- To review current knowledge on the association between HPV and bladder cancer.
- To discuss the implications of HPV detection for patient management and prognosis.
Main Methods:
- Literature review of studies investigating HPV DNA in bladder cancer.
- Analysis of HPV DNA incidence, HPV types, and correlation with tumor grade, stage, and patient outcomes.
- Examination of molecular mechanisms involving HPV oncoproteins (E6, E7) in bladder carcinogenesis.
Main Results:
- HPV DNA detection in bladder cancer varies significantly across studies.
- HPV-positive cases are often high-grade and high-stage, associated with poorer survival and increased recurrence post-treatment.
- HPV oncoproteins E6 and E7 may contribute to bladder cancer development by affecting tumor suppressor proteins p53 and pRb.
Conclusions:
- HPV infection may have prognostic significance in bladder cancer.
- Further research is needed to translate HPV detection into clinical patient management strategies.