Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multifocal choroiditis with subretinal fibrosis]

S Onoda1, K Shibuya, H Miyasaka

  • 1Department of Ophthalmology, Teikyo University Medical School, Tokyo, Japan.

Nippon Ganka Gakkai Zasshi
|October 6, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastroblastoma with MALAT1-GLI1 fusion gene: a case report.

Hong Kong medical journal = Xianggang yi xue za zhi·2025
Same author

Leaf phosphorus allocation patterns and photosynthetic phosphorus-use-efficiency in phosphorus-limited conditions.

Plant biology (Stuttgart, Germany)·2025
Same author

[Aqueous extract of Chuan Xiong Rhizoma enhances inhibitory effect of temozolomide against brain metastasis of melanoma in mice].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2024
Same author

[AZD9291 suppresses proliferation and migration of nasopharyngeal carcinoma cells by inhibiting the PI3K-AKT-mTOR pathway].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2022
Same author

Tumor microenvironment and its clinicopathological and prognostic associations in surgically resected cutaneous angiosarcoma.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2022
Same author

[<i>Chuanxiong Rhizoma</i> inhibits brain metastasis of lung cancer through multiple active ingredients acting on multiple targets, pathways and biological functions].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2021
Same journal

Guidance of Medical Care for Familial Exudative Vitreoretinopathy：Research on Rare and Intractable Diseases, Health and Labour Sciences Research Grants.

Nippon Ganka Gakkai zasshi·2018
Same journal

Steroid Resistant Vogt-Koyanagi-Harada Disease Treated Effectively with Cyclosporine.

Nippon Ganka Gakkai zasshi·2018
Same journal

The Effect of Low-dose Cyclosporine (100 mg Once Daily) for Chronic Vogt-Koyanagi-Harada Disease.

Nippon Ganka Gakkai zasshi·2018
Same journal

Clinical Classification of Degree of Deficiency in Color Defectiveness: Simulations by Changing the Total Number of Caps or Saturation of Farnsworth Dichotomous Test D-15.

Nippon Ganka Gakkai zasshi·2018
Same journal

Accelerated Epithelial Proliferation in a Rabbit Model of Bullous Keratopathy.

Nippon Ganka Gakkai zasshi·2018
Same journal

Non-infectious Uveitis and Immunosuppressants：Where We Stand and What the Future Holds.

Nippon Ganka Gakkai zasshi·2018
See all related articles

Multifocal choroiditis with subretinal fibrosis shows distinct patterns on indocyanine green angiography (IA) compared to fluorescein angiography (FAG). IA highlights initial choriocapillaris damage, revealing larger hypofluorescent areas indicative of retinal pigment epithelium-choriocapillaris complex compromise.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Multifocal choroiditis (MFC) is an inflammatory condition affecting the choroid.
  • Subretinal fibrosis can be a complication of MFC, potentially impacting vision.
  • Fluorescein angiography (FAG) and indocyanine green angiography (IA) are key imaging modalities in diagnosing and monitoring posterior uveitis.

Observation:

  • Two cases of MFC with subretinal fibrosis were evaluated using FAG and IA.
  • Case 1: A 14-year-old myopic female with peripheral lesions and progressive subretinal fibrosis.
  • Case 2: An 18-year-old high myopic male with posterior pole lesions, choroidal neovascularization, and peripheral fibrosis.

Findings:

  • FAG showed hypofluorescence in lesion centers and hyperfluorescence at edges, with some window defects and staining.

Related Experiment Videos

  • IA revealed widespread, persistent hypofluorescence from early stages, with visible major choroidal vessels.
  • IA demonstrated larger hypofluorescent areas than FAG and funduscopy, suggesting initial choriocapillaris damage.

    • Implications:

    • IA is crucial for detecting early choriocapillaris compromise in MFC with subretinal fibrosis.
    • The imaging findings suggest a sequential damage process involving the retinal pigment epithelium and choriocapillaris.
    • These insights aid in understanding the pathophysiology and potential management of this condition.