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Synthesis and bone resorption effect of alkoxy-substituted xanthones
Archiv Der Pharmazie
|July 1, 1997
Abstract:
A topological modification of ipriflavone 1, a recent antiosteoporotic drug, is described. The flavone moiety of 1 has been replaced by a xanthone one. Among the new derivatives, the 3,6-diisopropoxyxanthone (2a) has shown significant bone resorption inhibition in in vitro and in vivo tests.