Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxic epidermal necrolysis

J T Murphy1, G F Purdue, J L Hunt

  • 1Department of Surgery, University of Texas, Southwestern Medical Center, Dallas 75235-9031, USA.

The Journal of Burn Care & Rehabilitation
|October 6, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How phenotype guides management of the neuroendocrine carcinomas of the larynx.

The Journal of laryngology and otology·2018
Same author

Role of ancillary techniques in profiling unclassified laryngeal malignancies.

Virchows Archiv : an international journal of pathology·2018
Same author

Bilateral inverted papilloma: A report of two cases and review of the current literature.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2012
Same author

The Chernobyl thyroid cancer experience: pathology.

Clinical oncology (Royal College of Radiologists (Great Britain))·2011
Same author

Responses to active and passive wrist rotation in area 5 of awake monkeys.

Neuroscience letters·2009
Same author

Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression.

Virchows Archiv : an international journal of pathology·2008
Same journal

Efficacy of a short-term, intensive social skills training program for burned adolescents.

The Journal of burn care & rehabilitation·2005
Same journal

Celebrating progress in psychosocial rehabilitation: empirically validating the efficacy of social skills training and body image assessment for burn survivors.

The Journal of burn care & rehabilitation·2005
Same journal

Axillary burns: extended grafting and early splinting prevents contractures.

The Journal of burn care & rehabilitation·2005
Same journal

Impact of an inpatient rehabilitation facility on functional outcome and length of stay of burn survivors.

The Journal of burn care & rehabilitation·2005
Same journal

The Functional Independence Measure (FIM) and functional outcomes after a new approach to axillary burns.

The Journal of burn care & rehabilitation·2005
Same journal

Patients with epilepsy: a high-risk population prone to severe burns as a consequence of seizures while showering.

The Journal of burn care & rehabilitation·2005
See all related articles

Toxic epidermal necrolysis (TEN) is a severe skin reaction. Early referral and avoiding prolonged systemic steroids are crucial for reducing high mortality rates in TEN patients.

Area of Science:

  • Dermatology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Toxic epidermal necrolysis (TEN) is a rare but severe mucocutaneous reaction.
  • Often diagnosed initially in primary care, requiring specialized management.
  • High mortality rates are linked to treatment delays and prolonged systemic steroid use.

Purpose of the Study:

  • To analyze mortality rates in TEN patients treated at a regional burn center.
  • To identify factors contributing to poor outcomes, including delayed referral and steroid therapy.
  • To emphasize the importance of specialized care for severe TEN cases.

Main Methods:

  • Retrospective review of 44 consecutive TEN patients admitted over 14 years.
  • Analysis of precipitating factors, prehospital allergies, age, and total body surface area (TBSA) injury.

Related Experiment Videos

  • Comparison of characteristics between surviving and non-surviving patients.

    • Main Results:

    • Overall mortality rate was 36%.
    • Nonsurvivors were older (mean 61.6 years) with greater TBSA injury (mean 64.4%) compared to survivors.
    • Delayed referral (>1 week) and prolonged systemic steroid use were associated with excessive mortality.

    Conclusions:

    • TEN, despite being nonthermal, requires management by experts in severe thermal injury care.
    • Delayed transfer and inappropriate prolonged steroid therapy significantly increase TEN morbidity and mortality.
    • Prompt, specialized care is essential for improving outcomes in toxic epidermal necrolysis.