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Related Experiment Videos

A function for CD2 on murine B cells?

M C Keogh1, J Elliot, T Norton

  • 1Department of Immunology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.

Immunology and Cell Biology
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

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Mouse B cells expressing human CD2 do not proliferate when activated by anti-CD2 antibodies. This suggests CD2 ligation does not trigger a functional response in these B cells, unlike in T cells.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD2 is typically found on T cells and its function on B cells is not well understood.
  • Mouse B cells express CD2, possibly due to chromosomal translocations.

Purpose of the Study:

  • To investigate the expression and function of CD2 on B cells.
  • To determine if CD2 ligation can activate B cells.

Main Methods:

  • Generated transgenic mice expressing human CD2 in both B and T cell compartments.
  • Utilized activating anti-CD2 monoclonal antibodies to stimulate cells.
  • Assessed B cell proliferation and functional consequences following CD2 ligation.

Main Results:

  • Transgenic T cells expressing human CD2 showed proliferation upon anti-CD2 antibody stimulation.

Related Experiment Videos

  • B cells expressing similar levels of human CD2 did not proliferate in response to anti-CD2 antibodies.
  • No functional consequences were observed in B cells following CD2 ligation.

    • Conclusions:

    • CD2 ligation does not induce proliferation or a functional response in mouse B cells, despite their expression of the molecule.
    • The function of CD2 may be restricted to T cells, even when expressed ectopically in B cells.