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Axon guidance and somites

D Tannahill1, G M Cook, R J Keynes

  • 1Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK. dt10003@mole.bio.cam.ac.uk

Cell and Tissue Research
|October 10, 1997
PubMed
Summary

Spinal nerve development in vertebrate embryos reveals how axons navigate. Two mechanisms, contact repulsion and chemorepulsion, guide motor and sensory axons by

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Area of Science:

  • Developmental biology
  • Neuroscience
  • Molecular biology

Background:

  • Spinal nerve development in vertebrate embryos offers a model for studying axon pathfinding.
  • Developing axons are guided by surrounding tissues, involving complex molecular interactions.

Purpose of the Study:

  • To investigate the guidance mechanisms directing spinal axon trajectories.
  • To elucidate the roles of contact repulsion and chemorepulsion in axon pathfinding.

Main Methods:

  • Analysis of axon growth within mesodermal somites.
  • Investigation of guidance cues from surrounding embryonic tissues.

Main Results:

  • Motor and sensory axons navigate anterior half-somites due to contact repulsion from posterior half-somites.
  • Diffusible repellents from the notochord and dermamyotome govern sensory axon dorsoventral trajectories.

Conclusions:

  • 'Surround-repulsion' involving both contact repulsion and chemorepulsion dictates spinal axon paths.
  • Further research is needed to identify specific guidance molecules and their functions.

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