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Updated: Aug 9, 2026

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
Published on: January 10, 2015
How do wiring molecules specify cortical connections?
1INSERM Unité 371 "Cerveau et Vision", 18 Avenue du Doyen Lépine, F-69500 Bron, France. bolz@lyon151.inserm.fr
Abstract:
The laminar and columnar organization of the cortex is reflected in the projections to and from the cortex and in the intracortical connections. During development of the cerebral cortex, growing axons are able to distinguish between the different cortical layers, and cortical axons originating from different laminae respond to different layer-specific signals. Here we consider some experimental systems for identifying mechanisms that contribute to the elaboration of layer-specific cortical connections.
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