Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How do wiring molecules specify cortical connections?

J Bolz1, V Castellani

  • 1INSERM Unité 371 "Cerveau et Vision", 18 Avenue du Doyen Lépine, F-69500 Bron, France. bolz@lyon151.inserm.fr

Cell and Tissue Research
|October 10, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foot polydactyly and bipartite medial cuneiform: A case of co-occurrence in a Celtic skeleton from Verona (Italy).

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen·2015
Same author

Bacterial colonization of microbial biofilms in oral squamous cell carcinoma.

Clinical oral investigations·2013
Same author

Neurogenesis in the adult dentate gyrus after cortical infarcts: effects of infarct location, N-methyl-D-aspartate receptor blockade and anti-inflammatory treatment.

Neuroscience·2005
Same author

The function of neuropilin/L1 complex.

Advances in experimental medicine and biology·2003
Same author

Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A.

The EMBO journal·2002
Same author

Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same journal

Correction to: Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Deletion of CEACAM1 does not affect retinal and choroidal morphology or transcriptome.

Cell and tissue research·2026
Same journal

Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.

Cell and tissue research·2026
Same journal

Gill ionocytes of the Lake Magadi tilapia (Oreochromis Alcolapia grahami), an extremophilic teleost native to a highly alkaline environment.

Cell and tissue research·2026
Same journal

Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Effects of gestational protein restriction on autophagy dynamics during odontogenesis.

Cell and tissue research·2026
See all related articles

Developing brain connections show layer-specific targeting. Axons recognize and respond to signals from different cortical layers, guiding the formation of precise neural circuits.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The cerebral cortex exhibits distinct laminar and columnar organization.
  • This organization is evident in both intracortical and corticocortical connections.
  • Axons navigating the developing cortex must exhibit layer-specific targeting.

Purpose of the Study:

  • To explore experimental systems for identifying mechanisms of layer-specific cortical connection development.
  • To understand how growing axons distinguish between cortical layers.
  • To investigate the role of layer-specific signals in guiding axonal projections.

Main Methods:

  • Review of experimental systems for studying cortical development.
  • Analysis of axonal guidance mechanisms.

Related Experiment Videos

  • Examination of layer-specific signaling in the cerebral cortex.

    • Main Results:

    • Growing axons demonstrate an ability to differentiate between cortical layers.
    • Axons originating from specific cortical laminae are responsive to distinct layer-specific cues.
    • These interactions are crucial for establishing precise intracortical and corticocortical connections.

    Conclusions:

    • Layer-specific signaling plays a critical role in the precise wiring of the developing cerebral cortex.
    • Understanding these mechanisms is key to comprehending neural circuit formation.
    • Further research into these experimental systems will elucidate the molecular basis of cortical development.