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Transitional progressive multiple sclerosis: a clinical and imaging study

A Gayou1, B Brochet, V Dousset

  • 1Department of Neurology, Pellegrin Hospital, and University Victor Segalen, Bordeaux, France.

Journal of Neurology, Neurosurgery, and Psychiatry
|November 5, 1997
PubMed
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Transitional progressive multiple sclerosis (TPMS) shows similar early disease characteristics to secondary progressive multiple sclerosis (SPMS). However, TPMS progression trends more closely with primary progressive multiple sclerosis (PPMS).

Area of Science:

  • Neurology
  • Neuroimmunology
  • Clinical Neuroscience

Background:

  • Multiple sclerosis (MS) presents with diverse clinical courses.
  • Transitional progressive multiple sclerosis (TPMS) is a less understood clinical form.
  • TPMS is characterized by a progressive course emerging years after an initial isolated neurological event.

Purpose of the Study:

  • To determine the prevalence of TPMS within a clinical population.
  • To investigate the natural history and clinical course of TPMS.
  • To compare TPMS with other progressive forms of multiple sclerosis (MS).

Main Methods:

  • Retrospective analysis of 214 definite or probable MS outpatients.
  • Prevalence of TPMS, secondary progressive MS (SPMS), and primary progressive MS (PPMS) was calculated.

Related Experiment Videos

  • Prospective one-year follow-up of a TPMS subgroup using clinical indices and MRI.

    • Main Results:

    • TPMS prevalence was 12 out of 214 MS patients.
    • Early disease features of TPMS were comparable to SPMS.
    • No significant differences were observed between TPMS, SPMS, and PPMS during the follow-up period.

    Conclusions:

    • TPMS shares initial clinical similarities with SPMS.
    • A trend suggests TPMS progression aligns more with PPMS regarding disability and MRI lesions.
    • Further research is needed to fully elucidate the distinct natural history of TPMS.