Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cutaneous microcirculation: ultrastructure and microanatomical organization

I M Braverman1

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

Microcirculation (New York, N.Y. : 1994)
|November 5, 1997
PubMed
Summary

This study details the skin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pioneers in Dermatology and Venereology: an interview with Prof. Irwin Braverman.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus.

Lupus·2004
Same author

Use of fine art to enhance visual diagnostic skills.

JAMA·2001
Same author

The cutaneous microcirculation.

The journal of investigative dermatology. Symposium proceedings·2001
Same author

Protective effects of erythema nodosum in coccidioidomycosis.

Lancet (London, England)·1999
Same author

PURPLE (oops! Atrophie blanche) revisited.

Archives of dermatology·1999

Area of Science:

  • Dermatology
  • Vascular Biology
  • Microcirculation Research

Background:

  • The skin's microcirculation comprises two horizontal plexuses at different depths.
  • Arterioles and venules connect these plexuses, with capillaries forming nutritive loops.
  • Specialized smooth muscle cells and venous valves regulate blood flow within the skin.

Purpose of the Study:

  • To elucidate the structural organization of the cutaneous microcirculation.
  • To investigate the functional dynamics of blood flow regulation in the skin.
  • To establish methods for analyzing microvascular composition and its role in skin physiology and pathology.

Main Methods:

  • Detailed analysis of microvascular architecture using light and electron microscopy.
  • Application of Laser Doppler flowmetry (LDF) to measure red blood cell flux and concentration.
  • Development of topographic mapping techniques to visualize microvascular distribution.

Main Results:

  • Identified distinct arteriolar and venular components within the microcirculation.
  • Demonstrated localized vasomotion in ascending arterioles using LDF.
  • Created topographic maps defining 1-mm3 skin volumes based on microvascular composition.

Conclusions:

  • The study provides a detailed map of skin microvascular organization and function.
  • Laser Doppler flowmetry combined with microscopy enables precise analysis of microvascular segments.
  • This approach facilitates the study of both normal skin physiology and disease pathogenesis involving the microvasculature.

Related Experiment Videos