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beta-Amyloid-induced cerebrovascular endothelial dysfunction
T Thomas1, C McLendon, E T Sutton
1Department of Psychiatry, College of Medicine, University of South Florida, Tampa 33613, USA.
Annals of the New York Academy of Sciences
|November 5, 1997
Abstract:
Cerebrovascular effects of beta-amyloid were investigated using bovine mid-cerebral arteries. beta-amyloid-induced endothelial damage was evidenced by increased vasoconstriction, diminished vasodilation and was evident on electron microscopy. The endothelial dysfunction was mediated by reactive oxygen radicals. Vascular damage by beta-amyloid may be an early event in the development of the pathology of Alzheimer's disease.