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Etiologic factors in Peyronie's disease
S Muralidhar1, B Kumar, S K Sharma
1Department of Dermatology, Institute of Medical Education and Research, Chandigarh, India.
Background:
The etiology of Peyonie's disease remains a mystery. An attempt is made to resolve this.
Materials And Methods:
A total of 25 patients with Peyronie's disease were examined and investigated for the presence of various implicated etiologic factors.
Results:
Of the 25 patients examined, two presented with ischemic heart disease, 10 with hypertension, 10 with asymptomatic hyperuricemia, 18 with hypercholesterolemia, two with fibrosing disorders, two with autoimmune disorders, and three with diabetes mellitus. None had any sexually transmitted disease. Seven of the 10 hypertensive patients had received beta-blockers. On comparing the prevalence of these factors between patients and the general population, a significant association was found between hypertension, hypercholesterolemia, hyperuricemia, and Peyronie's disease.
Conclusions:
Known factors, such as hypertension and hypercholesterolemia, lead to weakening of the vasculature and its rupture during coitus. This leads to the formation of a hematoma and its subsequent organization in predisposed individuals to fibrous plaques. The identification and treatment of these factors might prevent, secondarily, the development of Peyronie's disease.