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CD26 as a positive regulator of HIV envelope-glycoprotein induced apoptosis in CD4+ T cells
E Jacotot1, C Callebaut, J Blanco
1Unité de Virologie et Immunologie Cellulaire, UA CNRS 1157 Institut Pasteur, Paris, France.
Advances in Experimental Medicine and Biology
|January 1, 1997
Abstract:
The membrane-expressed HIV-1 envelope glycoprotein complex, gp120/gp41, has been shown to be responsible for the initiation of cell killing by apoptosis in CD4+ T cells. By using two experimental approaches we demonstrate that CD26, independent of its DPP IV activity, appears to be implicated in this function of the gp120/gp41 complex to initiate apoptosis.