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The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminal deleted Kv1.4 alpha-subunits
R L Rasmusson1, S Wang, R C Castellino
1Department of Biomedical Engineering, School of Engineering, Duke University, Durham, NC 27708, USA.
Advances in Experimental Medicine and Biology
|January 1, 1997
Abstract:
A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of alpha-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kv beta 1.2, modifies intrinsic alpha-subunit C-type inactivation. N-type inactivation and open channel block have been proposed to increase the rate of development of C-type inactivation. We demonstrate here that Kv beta 1.2 has kinetic properties which are consistent with rapid open channel block.